Nearly 1 out of 3 patients with depression do not experience complete resolution of symptoms from using standard antidepressants such as SSRIs(selective serotonin reuptake inhibitors) and SNRIs (serotonin-norepinephrine reuptake inhibitors). Patients within sufficient folate levels are less likely to respond to treatment and more likely to experience a relapse. Medical foods are intended for those whose capacity to absorb or metabolize a certain nutrient is impaired. Research has shown that Deplin® is particularly effective for those with low levels of L-methylfolate and major depressive disorder or schizophrenia.ĭeplin® is not an antidepressant in itself but a ‘medical food’ that provides the necessary nutrients to make your brain more responsive to an antidepressant. It is usually prescribed to people who are found to have low levels of L-methylfolate in the body.Īlthough Deplin® is not an antidepressant or antipsychotic, it is often used as an adjunctive treatment alongside antidepressant medication. However, supplements that contain bioavailable folate have been shown to improve depressive symptoms and increase these mood-dependent neurotransmitters.ĭeplin® provides this kind of folate so that it is readily available for making the brain’s “happy chemicals”. serotonin, dopamine, and norepinephrine). Low MTHFR enzyme levels lead to low methylenetetrahydrofolate, which in turn leads to lower levels of monoamines (i.e. Taking ordinary folic acid is ineffective because it can’t be utilized for the creation of neurotransmitters in the brain. This polymorphism means that many people are unable to convert folic acid into the form called L-methylfolate, which is able to pass through the “blood-brain barrier” and enter the central nervous system. People with MTHFR genetic polymorphisms cannot metabolize folic acid to L-methylfolate. People with major depression or certain psychiatric disorders are often found to be low in these brain chemicals, which has led researchers to link folate deficiency with depression. It is a synthetic form of folate that has already been converted to active L-methylfolate.įolate plays a major role in the synthesis of key brain chemical messengers, including serotonin, norepinephrine, and dopamine. The solution for some people may be a specialized nutrient, methylfolate.ĭeplin® is a prescription medication but is classified as a prescription ‘medical food’ rather than a drug. Between 10 to 35% of these people are affected by treatment-resistant depression (TRD), in which they are unable to find relief with antidepressant medications alone. According to NCHS data, around 8.1% of American adults aged 20 and over suffer from depression in any given 2-week period.
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